A predicted genome-wide human interactome. We integrated a wide range of computational evidences for the de-novo prediction of physical protein interactions. The database also lists known, experimentally tested interactions from various other popular sources.
- Read the paper (PDF)
- PubMed entry
- Access the database
Topology of functional networks predicts physical binding of proteins
The topology of molecular networks provides information about the certainty and nature of individual interactions. We have evaluated seven different network features extracted from the topology of functional genetic networks and we have quantified their ability to classify interactions into different types of physical protein associations.
Using this framework we have predicted protein-protein interactions for fission yeast (Schizosaccharomyces pombe).
- Paper
- Predicted fission yeast interactions (Suppl. Table 1, containing only newly predicted interactions without known once)